diff --git a/newsfragments/3717.minor b/newsfragments/3717.minor
new file mode 100644
index 000000000..e69de29bb
diff --git a/tox.ini b/tox.ini
index 5f500b49d..e7ce93f88 100644
--- a/tox.ini
+++ b/tox.ini
@@ -281,6 +281,8 @@ deps =
     # PyInstaller 4.0 drops Python 2 support.  When we finish porting to
     # Python 3 we can reconsider this constraint.
     pyinstaller < 4.0
+    # 2021.5.13 broke on Windows. See https://github.com/erocarrera/pefile/issues/318
+    pefile < 2021.5.13 ; platform_system == "Windows"
 # Setting PYTHONHASHSEED to a known value assists with reproducible builds.
 # See https://pyinstaller.readthedocs.io/en/stable/advanced-topics.html#creating-a-reproducible-build
 setenv=PYTHONHASHSEED=1