diff --git a/src/api/annotation/AnnotationAPI.js b/src/api/annotation/AnnotationAPI.js
index 72f3d74d95..f13a26de58 100644
--- a/src/api/annotation/AnnotationAPI.js
+++ b/src/api/annotation/AnnotationAPI.js
@@ -76,6 +76,9 @@ const ANNOTATION_LAST_CREATED = 'annotationLastCreated';
  * @constructor
  */
 export default class AnnotationAPI extends EventEmitter {
+  /** @type {Map<ANNOTATION_TYPES, Array<(a, b) => boolean >>} */
+  #targetComparatorMap;
+
   /**
    * @param {OpenMCT} openmct
    */
@@ -84,6 +87,7 @@ export default class AnnotationAPI extends EventEmitter {
     this.openmct = openmct;
     this.availableTags = {};
     this.namespaceToSaveAnnotations = '';
+    this.#targetComparatorMap = new Map();
 
     this.ANNOTATION_TYPES = ANNOTATION_TYPES;
     this.ANNOTATION_TYPE = ANNOTATION_TYPE;
@@ -246,15 +250,16 @@ export default class AnnotationAPI extends EventEmitter {
   /**
    * @method getAnnotations
    * @param {Identifier} domainObjectIdentifier - The domain object identifier to use to search for annotations. For example, a telemetry object identifier.
+   * @param {AbortSignal} abortSignal - An abort signal to cancel the search
    * @returns {DomainObject[]} Returns an array of annotations that match the search query
    */
-  async getAnnotations(domainObjectIdentifier) {
+  async getAnnotations(domainObjectIdentifier, abortSignal = null) {
     const keyStringQuery = this.openmct.objects.makeKeyString(domainObjectIdentifier);
     const searchResults = (
       await Promise.all(
         this.openmct.objects.search(
           keyStringQuery,
-          null,
+          abortSignal,
           this.openmct.objects.SEARCH_TYPES.ANNOTATIONS
         )
       )
@@ -384,7 +389,8 @@ export default class AnnotationAPI extends EventEmitter {
     const combinedResults = [];
     results.forEach((currentAnnotation) => {
       const existingAnnotation = combinedResults.find((annotationToFind) => {
-        return _.isEqual(currentAnnotation.targets, annotationToFind.targets);
+        const { annotationType, targets } = currentAnnotation;
+        return this.areAnnotationTargetsEqual(annotationType, targets, annotationToFind.targets);
       });
       if (!existingAnnotation) {
         combinedResults.push(currentAnnotation);
@@ -460,4 +466,35 @@ export default class AnnotationAPI extends EventEmitter {
 
     return breakApartSeparateTargets;
   }
+
+  /**
+   * Adds a comparator function for a given annotation type.
+   * The comparator functions will be used to determine if two annotations
+   * have the same target.
+   * @param {ANNOTATION_TYPES} annotationType
+   * @param {(t1, t2) => boolean} comparator
+   */
+  addTargetComparator(annotationType, comparator) {
+    const comparatorList = this.#targetComparatorMap.get(annotationType) ?? [];
+    comparatorList.push(comparator);
+    this.#targetComparatorMap.set(annotationType, comparatorList);
+  }
+
+  /**
+   * Compare two sets of targets to see if they are equal. First checks if
+   * any targets comparators evaluate to true, then falls back to a deep
+   * equality check.
+   * @param {ANNOTATION_TYPES} annotationType
+   * @param {*} targets
+   * @param {*} otherTargets
+   * @returns true if the targets are equal, false otherwise
+   */
+  areAnnotationTargetsEqual(annotationType, targets, otherTargets) {
+    const targetComparatorList = this.#targetComparatorMap.get(annotationType);
+    return (
+      (targetComparatorList?.length &&
+        targetComparatorList.some((targetComparator) => targetComparator(targets, otherTargets))) ||
+      _.isEqual(targets, otherTargets)
+    );
+  }
 }
diff --git a/src/api/annotation/AnnotationAPISpec.js b/src/api/annotation/AnnotationAPISpec.js
index 7be711d235..318220ba2e 100644
--- a/src/api/annotation/AnnotationAPISpec.js
+++ b/src/api/annotation/AnnotationAPISpec.js
@@ -265,4 +265,52 @@ describe('The Annotation API', () => {
       expect(results.length).toEqual(0);
     });
   });
+
+  describe('Target Comparators', () => {
+    let targets;
+    let otherTargets;
+    let comparator;
+
+    beforeEach(() => {
+      targets = {
+        fooTarget: {
+          foo: 42
+        }
+      };
+      otherTargets = {
+        fooTarget: {
+          bar: 42
+        }
+      };
+      comparator = (t1, t2) => t1.fooTarget.foo === t2.fooTarget.bar;
+    });
+
+    it('can add a comparator function', () => {
+      const notebookAnnotationType = openmct.annotation.ANNOTATION_TYPES.NOTEBOOK;
+      expect(
+        openmct.annotation.areAnnotationTargetsEqual(notebookAnnotationType, targets, otherTargets)
+      ).toBeFalse(); // without a comparator, these should NOT be equal
+      // Register a comparator function for the notebook annotation type
+      openmct.annotation.addTargetComparator(notebookAnnotationType, comparator);
+      expect(
+        openmct.annotation.areAnnotationTargetsEqual(notebookAnnotationType, targets, otherTargets)
+      ).toBeTrue(); // the comparator should make these equal
+    });
+
+    it('falls back to deep equality check if no comparator functions', () => {
+      const annotationTypeWithoutComparator = openmct.annotation.ANNOTATION_TYPES.GEOSPATIAL;
+      const areEqual = openmct.annotation.areAnnotationTargetsEqual(
+        annotationTypeWithoutComparator,
+        targets,
+        targets
+      );
+      const areNotEqual = openmct.annotation.areAnnotationTargetsEqual(
+        annotationTypeWithoutComparator,
+        targets,
+        otherTargets
+      );
+      expect(areEqual).toBeTrue();
+      expect(areNotEqual).toBeFalse();
+    });
+  });
 });
diff --git a/src/plugins/inspectorViews/annotations/AnnotationsInspectorView.vue b/src/plugins/inspectorViews/annotations/AnnotationsInspectorView.vue
index fcf2f29653..5e990943fc 100644
--- a/src/plugins/inspectorViews/annotations/AnnotationsInspectorView.vue
+++ b/src/plugins/inspectorViews/annotations/AnnotationsInspectorView.vue
@@ -41,7 +41,6 @@
 
 <script>
 import TagEditor from './tags/TagEditor.vue';
-import _ from 'lodash';
 
 export default {
   components: {
@@ -123,6 +122,7 @@ export default {
     }
   },
   async mounted() {
+    this.abortController = null;
     this.openmct.annotation.on('targetDomainObjectAnnotated', this.loadAnnotationForTargetObject);
     this.openmct.selection.on('change', this.updateSelection);
     await this.updateSelection(this.openmct.selection.get());
@@ -190,20 +190,34 @@ export default {
       }
     },
     async loadAnnotationForTargetObject(target) {
-      const targetID = this.openmct.objects.makeKeyString(target.identifier);
-      const allAnnotationsForTarget = await this.openmct.annotation.getAnnotations(
-        target.identifier
-      );
-      const filteredAnnotationsForSelection = allAnnotationsForTarget.filter((annotation) => {
-        const matchingTargetID = Object.keys(annotation.targets).filter((loadedTargetID) => {
-          return targetID === loadedTargetID;
-        });
-        const fetchedTargetDetails = annotation.targets[matchingTargetID];
-        const selectedTargetDetails = this.targetDetails[matchingTargetID];
+      // If the user changes targets while annotations are loading,
+      // abort the previous request.
+      if (this.abortController !== null) {
+        this.abortController.abort();
+      }
 
-        return _.isEqual(fetchedTargetDetails, selectedTargetDetails);
-      });
-      this.loadNewAnnotations(filteredAnnotationsForSelection);
+      this.abortController = new AbortController();
+
+      try {
+        const allAnnotationsForTarget = await this.openmct.annotation.getAnnotations(
+          target.identifier,
+          this.abortController.signal
+        );
+        const filteredAnnotationsForSelection = allAnnotationsForTarget.filter((annotation) =>
+          this.openmct.annotation.areAnnotationTargetsEqual(
+            this.annotationType,
+            this.targetDetails,
+            annotation.targets
+          )
+        );
+        this.loadNewAnnotations(filteredAnnotationsForSelection);
+      } catch (err) {
+        if (err.name !== 'AbortError') {
+          throw err;
+        }
+      } finally {
+        this.abortController = null;
+      }
     }
   }
 };
diff --git a/src/plugins/notebook/components/Notebook.vue b/src/plugins/notebook/components/Notebook.vue
index 52cb66a69e..4564bbac70 100644
--- a/src/plugins/notebook/components/Notebook.vue
+++ b/src/plugins/notebook/components/Notebook.vue
@@ -306,13 +306,22 @@ export default {
     this.getSearchResults = debounce(this.getSearchResults, 500);
     this.syncUrlWithPageAndSection = debounce(this.syncUrlWithPageAndSection, 100);
   },
-  async mounted() {
-    await this.loadAnnotations();
+  async created() {
+    this.transaction = null;
+    this.abortController = new AbortController();
+    try {
+      await this.loadAnnotations();
+    } catch (err) {
+      if (err.name !== 'AbortError') {
+        throw err;
+      }
+    }
+  },
+  mounted() {
     this.formatSidebar();
     this.setSectionAndPageFromUrl();
 
     this.openmct.selection.on('change', this.updateSelection);
-    this.transaction = null;
 
     window.addEventListener('orientationchange', this.formatSidebar);
     window.addEventListener('hashchange', this.setSectionAndPageFromUrl);
@@ -324,6 +333,7 @@ export default {
     );
   },
   beforeDestroy() {
+    this.abortController.abort();
     if (this.unlisten) {
       this.unlisten();
     }
@@ -387,8 +397,10 @@ export default {
       this.lastLocalAnnotationCreation = this.domainObject.annotationLastCreated ?? 0;
 
       const foundAnnotations = await this.openmct.annotation.getAnnotations(
-        this.domainObject.identifier
+        this.domainObject.identifier,
+        this.abortController.signal
       );
+
       foundAnnotations.forEach((foundAnnotation) => {
         const targetId = Object.keys(foundAnnotation.targets)[0];
         const entryId = foundAnnotation.targets[targetId].entryId;
@@ -425,7 +437,11 @@ export default {
           : [...filteredPageEntriesByTime].reverse();
 
       if (this.lastLocalAnnotationCreation < this.domainObject.annotationLastCreated) {
-        this.loadAnnotations();
+        this.loadAnnotations().catch((err) => {
+          if (err.name !== 'AbortError') {
+            throw err;
+          }
+        });
       }
     },
     changeSelectedSection({ sectionId, pageId }) {
diff --git a/src/plugins/plot/MctPlot.vue b/src/plugins/plot/MctPlot.vue
index c0d0e18e24..7d00b934fc 100644
--- a/src/plugins/plot/MctPlot.vue
+++ b/src/plugins/plot/MctPlot.vue
@@ -339,6 +339,9 @@ export default {
       this.cursorGuide = newCursorGuide;
     }
   },
+  created() {
+    this.abortController = new AbortController();
+  },
   mounted() {
     this.yAxisIdVisibility = {};
     this.offsetWidth = 0;
@@ -398,6 +401,7 @@ export default {
     this.loaded = true;
   },
   beforeDestroy() {
+    this.abortController.abort();
     this.openmct.selection.off('change', this.updateSelection);
     document.removeEventListener('keydown', this.handleKeyDown);
     document.removeEventListener('keyup', this.handleKeyUp);
@@ -621,7 +625,8 @@ export default {
       await Promise.all(
         this.seriesModels.map(async (seriesModel) => {
           const seriesAnnotations = await this.openmct.annotation.getAnnotations(
-            seriesModel.model.identifier
+            seriesModel.model.identifier,
+            this.abortController.signal
           );
           rawAnnotationsForPlot.push(...seriesAnnotations);
         })
@@ -1524,7 +1529,11 @@ export default {
         this.endMarquee();
       }
 
-      this.loadAnnotations();
+      this.loadAnnotations().catch((err) => {
+        if (err.name !== 'AbortError') {
+          throw err;
+        }
+      });
     },
 
     zoom(zoomDirection, zoomFactor) {
diff --git a/src/ui/layout/search/AnnotationSearchResult.vue b/src/ui/layout/search/AnnotationSearchResult.vue
index e59be52449..1f0fe22449 100644
--- a/src/ui/layout/search/AnnotationSearchResult.vue
+++ b/src/ui/layout/search/AnnotationSearchResult.vue
@@ -98,6 +98,13 @@ export default {
         }
 
         return 'Could not find any matching Notebook entries';
+      } else if (
+        this.result.annotationType === this.openmct.annotation.ANNOTATION_TYPES.GEOSPATIAL
+      ) {
+        const targetID = Object.keys(this.result.targets)[0];
+        const { layerName, name } = this.result.targets[targetID];
+
+        return layerName ? `${layerName} - ${name}` : name;
       } else {
         return this.result.targetModels[0].name;
       }
@@ -133,7 +140,8 @@ export default {
           // if we're not on the correct page, navigate to the object,
           // then wait for the selection event to fire before issuing a new selection
           if (
-            this.result.annotationType === this.openmct.annotation.ANNOTATION_TYPES.PLOT_SPATIAL
+            this.result.annotationType === this.openmct.annotation.ANNOTATION_TYPES.PLOT_SPATIAL ||
+            this.result.annotationType === this.openmct.annotation.ANNOTATION_TYPES.GEOSPATIAL
           ) {
             this.openmct.selection.on('change', this.clickedPlotAnnotation);
           }